Recent Progresses in Cancer Nanotherapeutics Design Using Artemisinins as Free Radical Precursors.
作者： Yalan Wu , Qingping Zeng , Zhiwen Qi , Tao Deng , Fang Liu
关键词: Cancer treatment 、 The arts 、 Engineering 、 Engineering ethics 、 Drug Activation 、 Advanced cancer 、 Artemisinins
摘要: Artemisinin and its derivatives (ARTs) are sort of important antimalarials, which exhibit a wide range biological activities including anticancer effect. To solve the issues regarding poor solubility limited bioavailability ARTs, nanoformulation ARTs has thus emerged as promising strategy for cancer treatment. A common consideration on nanoARTs design lies ARTs' delivery controlled release, where commonly regarded hydrophobic drugs. Based mechanism that activation relies ferrous ions (Fe2+) or Fe2+-bonded complexes, new designs to enhance have attracted great interests advanced nanotherapy. Among these developments, nanoparticle can accelerate become major consideration, been radical precursors. This review mainly focused most recent developments nanotherapeutics basis drug activation. The basic principles in those will be summarized, few excellent cases also discussed detail.
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