Intramolecular signal transduction in c‐Jun.

摘要: The DNA-binding activity of c-Jun is determined by the phosphorylation state a cluster threonine and serine residues located near its COOH-terminus. We have analyzed events that lead to activation via dephosphorylation these sites in response phorbol esters. Our results indicate COOH-terminal an indirect consequence separate event targeted NH2-terminus c-Jun. Thus, potential, caused dephosphorylation, may not require regulation kinase/phosphatase system brings about this change, but rather alteration accessibility phosphoacceptor