Clinical impact of rapid in vitro susceptibility testing and bacterial identification.

作者: G V Doern , R Vautour , M Gaudet , B Levy

DOI: 10.1128/JCM.32.7.1757-1762.1994

关键词: Prospective cohort studyPediatricsMedicineMortality rateAntimicrobialRandomized controlled trialInternal medicineClinical trialIntubationTest (assessment)Susceptibility testingMicrobiology (medical)

摘要: During the past decade, a variety of instrument-assisted bacterial identification and antimicrobial susceptibility test systems have been developed which permit provision results in matter hours rather than days, as has case with traditional overnight procedures. These newer rapid techniques are much more expensive older methods. It presumed but not proven that clinical benefits testing to patients infection offset added cost. The intent this study was objectively define impact testing. A 1-year performed infected, hospitalized tertiary-care, teaching, medical center were randomly assigned one two groups: for whom by using semi-automated, rapid, same-day procedure those accomplished techniques. groups compared respect numerous demographic descriptors, then monitored prospectively through end their hospitalization aim determining whether there existed defineable differences management outcome between groups. mean lengths time group 11.3 9.6 h, respectively. In group, these values 19.6 25.9 respectively (P 100 descriptors. With regard measures outcome, also same both Mortality rates however, lower (i.e., 8.8% versus 15.3%). Similarly, statistically significantly fewer laboratory studies, imaging procedures, days intubation, an intensive or intermediate-care area observed group. Rapid associated shortened elapsed prior alterations therapy. Lastly, patient costs indicate microbiology can major on care infection.

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