In the eye of the storm: T cell behavior in the inflammatory microenvironment.

摘要: Coordinated unfolding of innate and adaptive immunity is key to the development protective immune responses. This functional integration occurs within inflamed tissue, a microenvironment enriched with factors released by subsequently cells injured tissue itself. T lymphocytes are players in ensuing their proper function instrumental successful outcome protection. The site inflammation “harsh” environment which exposed numerous that might influence behavior. Low pH oxygen concentration, high lactate organic acid content as well free fatty acids reactive species found inflammatory microenvironment. All these components affect other during response impact on chronic inflammation. We here overview effects number present cell migration discuss potential relevance targets for therapeutic intervention autoimmune diseases.