Acute and Chronic Effects of Aspirin Toxicity and Their Treatment

摘要: • Salicylate poisoning remains a major clinical hazard, usually resulting from accidental ingestions in preschool children, suicidal overdoses adults and teenagers, therapeutically acquired intoxication all ages. Alkalemia or acidemia, alkaluria aciduria, hypoglycemia hyperglycemia, water electrolyte imbalances may occur; nausea, vomiting, tinnitus, hyperpnea, hyperpyrexia, disorientation, coma, and/or convulsions are common. With chronic, induced salicylism, these symptoms be mistaken for the illness which salicylates were administered. For acute ingestions, magnitude of is clearly dose related. Blood level determinations good prognostic indicators but limited value salicylism. Fluid management mainstay therapy. Diuresis, hemodialysis, hemoperfusion effective, latter two rarely necessary. (Arch Intern Med1981;141:364-369)