Surfactant protein A without the interruption of Gly-X-Y repeats loses a kink of oligomeric structure and exhibits impaired phospholipid liposome aggregation ability.
作者： Tatsuki Uemura , Hitomi Sano , Tsuyoshi Katoh , Chiaki Nishitani , Hiroaki Mitsuzawa
DOI: 10.1021/BI061338U
关键词: Mutant 、 Liposome 、 Surfactant protein A 、 Phospholipid 、 Molecular biology 、 Pulmonary surfactant 、 Biophysics 、 Wild type 、 Dipalmitoylphosphatidylcholine 、 Biology 、 Protein A
摘要: … The mutants SP-A DEL and SP-A INS augmented liposome uptake by alveolar type II cells and inhibited secretion of phospholipids from type II cells at a level comparable to that of wild-…
acs.org
sci-hub.se 参考文章(19)
K Drickamer, M S Dordal, L Reynolds, Mannose-binding proteins isolated from rat liver contain carbohydrate-recognition domains linked to collagenous tails. Complete primary structures and homology with pulmonary surfactant apoprotein. Journal of Biological Chemistry. ,vol. 261, pp. 6878- 6887 ,(1986) , 10.1016/S0021-9258(19)62698-0
Tilman Voss, Harald Eistetter, Klaus P. Schäfer, Jürgen Engel, Macromolecular organization of natural and recombinant lung surfactant protein SP 28–36 Journal of Molecular Biology. ,vol. 201, pp. 219- 227 ,(1988) , 10.1016/0022-2836(88)90448-2
Shyra J. Gardai, Yi-Qun Xiao, Matthew Dickinson, Jerry A. Nick, Dennis R. Voelker, Kelly E. Greene, Peter M. Henson, By Binding SIRPα or Calreticulin/CD91, Lung Collectins Act as Dual Function Surveillance Molecules to Suppress or Enhance Inflammation Cell. ,vol. 115, pp. 13- 23 ,(2003) , 10.1016/S0092-8674(03)00758-X
Yasuhiro Suzuki, Yoko Fujita, Kumiko Kogishi, Reconstitution of Tubular Myelin from Synthetic Lipids and Proteins Associated with Pig Pulmonary Surfactant The American review of respiratory disease. ,vol. 140, pp. 75- 81 ,(1989) , 10.1164/AJRCCM/140.1.75
Fernando Sánchez-Barbero, Jochen Strassner, Rafael García-Cañero, Wolfram Steinhilber, Cristina Casals, Role of the degree of oligomerization in the structure and function of human surfactant protein A. Journal of Biological Chemistry. ,vol. 280, pp. 7659- 7670 ,(2005) , 10.1074/JBC.M410266200
Jo Rae Wright, Immunoregulatory functions of surfactant proteins. Nature Reviews Immunology. ,vol. 5, pp. 58- 68 ,(2005) , 10.1038/NRI1528
Machiko Ikegami, Baher M. Elhalwagi, Nades Palaniyar, Krista Dienger, Thomas Korfhagen, Jeffrey A. Whitsett, Francis X. McCormack, The Collagen-like Region of Surfactant Protein A (SP-A) Is Required for Correction of Surfactant Structural and Functional Defects in the SP-A Null Mouse * Journal of Biological Chemistry. ,vol. 276, pp. 38542- 38548 ,(2001) , 10.1074/JBC.M102054200
Jonathan M. Tyler, Daniel Branton, Rotary shadowing of extended molecules dried from glycerol. Journal of Ultrastructure Research. ,vol. 71, pp. 95- 102 ,(1980) , 10.1016/S0022-5320(80)90098-2
Hans-Jürgen Hoppe, Paul N. Barlow, Kenneth B.M. Reid, A parallel three stranded α-helical bundle at the nucleation site of collagen triple-helix formation FEBS Letters. ,vol. 344, pp. 191- 195 ,(1994) , 10.1016/0014-5793(94)00383-1
Wataru Tsunezawa, Hitomi Sano, Hitoshi Sohma, Francis X. McCormack, Dennis R. Voelker, Yoshio Kuroki, Site-directed mutagenesis of surfactant protein A reveals dissociation of lipid aggregation and lipid uptake by alveolar type II cells Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. ,vol. 1387, pp. 433- 446 ,(1998) , 10.1016/S0167-4838(98)00159-9