Patterns of energy substrates during ischemia measured in the brain by microdialysis.

摘要: The purpose of this study was to examine the patterns change in microdialysate concentrations glucose, lactate, pyruvate, and glutamate brain during periods hypoxia/ischemia identified by monitoring tissue pO2 (PbtO2). Of particular interest a better understanding what additional information could be obtained microdialysis parameters that not available from PbtO2. Fifty-seven patients admitted with severe traumatic injury who had placement both (PbtO2) probe were studied. perfused Ringer's solution at 0.3 μL/min dialysate collected 1-h intervals. concentration measured each sample. Changes examined episodes where PbtO2 decreased below 10 mm Hg. Ten decrease Hg observed p...