Apigenin potentiates the growth inhibitory effects by IKK-β-mediated NF-κB activation in pancreatic cancer cells

摘要: Apigenin is a potential chemopreventive agent for cancer prevention. Because of the central role transcription factor nuclear factor-κB (NF-κB) in pancreatic cancer, we investigated roles NF-κB apigenin-induced growth inhibition cells. It showed that apigenin reduced cell and induced apoptosis treatment down-regulated not only basal but also TNF-α-induced DNA binding activity, inhibitor κB (IκB)-α phosphorylation together with translocation p65 p50, it accompanied blockade IκB kinase (IKK)-β activity. Moreover, IKK blockage potentiated anticancer efficacy IKK-β overexpression attenuated inhibition. Additionally, (30 mg/kg) administration suppressed activation nude mice xenograft. These results indicated had to inhibit IKK-β-mediated activation, was valuable treatment.