Drug metabolizing capacity in vitro and in vivo--II. Correlations between hepatic microsomal monooxygenase markers in phenobarbital-induced rats.
作者： Diane E. Matthew , J.Brian Houston
DOI: 10.1016/0006-2952(90)90311-8
关键词: Biology 、 Cytochrome P450 、 Pharmacology 、 Tolbutamide 、 Phenobarbital 、 Theophylline 、 In vivo 、 Monooxygenase 、 Microsome 、 Enzyme inducer
摘要: Pretreatment with various doses of phenobarbital (PB) has been used to create a pool rats wide range hepatic microsomal monooxygenase activity systematically examine relationships between and within in vivo vitro markers. The clearance tolbutamide (TOL), theophylline (TH), antipyrine (AP) its metabolites were determined the same for microsome preparation assessment P450 content activities (via 7-ethoxycoumarin O-deethylase (ECOD), 7 ethoxyresorufin O-deethylase, 7-methoxycoumarin O-demethylase (MCOD) aldrin epoxidase determinations). A graded dose-response relationship was found PB treatment most but not all parameters. need careful selection as well markers is apparent from these studies. responsive parameters--TOL AP clearances, MCOD ECOD activities--were also those producing strongest vivo-in correlations. Despite diffuse nature induced response complement, good predictive TOL (r2 = 0.88).
elsevier.com
sci-hub.se 参考文章(37)
C R Wolf, S Seilman, F Oesch, R T Mayer, M D Burke, Multiple forms of cytochrome P-450 related to forms induced marginally by phenobarbital. Differences in structure and in the metabolism of alkoxyresorufins. Biochemical Journal. ,vol. 240, pp. 27- 33 ,(1986) , 10.1042/BJ2400027
G. C. Farrell, W. G. E. Cooksley, L. W. Powell, Drug metabolism in liver disease: Activity of hepatic microsomal metabolizing enzymes Clinical Pharmacology & Therapeutics. ,vol. 26, pp. 483- 492 ,(1979) , 10.1002/CPT1979264483
P.E. Thomas, L.M. Reik, D.E. Ryan, W. Levin, Regulation of three forms of cytochrome P-450 and epoxide hydrolase in rat liver microsomes. Effects of age, sex, and induction. Journal of Biological Chemistry. ,vol. 256, pp. 1044- 1052 ,(1981) , 10.1016/S0021-9258(19)70085-4
R H Levy, S D Nelson, S Nickelson, P J Wedlund, Linear relationship between cytochrome P-450 and carbamazepine clearance in rhesus monkey. Drug Metabolism and Disposition. ,vol. 10, pp. 480- 485 ,(1982)
John O Miners, Kerry J Smith, Richard A Robson, Michael E McManus, Maurice E Veronese, Donald J Birkett, Tolbutamide hydroxylation by human liver microsomes. Kinetic characterisation and relationship to other cytochrome P-450 dependent xenobiotic oxidations. Biochemical Pharmacology. ,vol. 37, pp. 1137- 1144 ,(1988) , 10.1016/0006-2952(88)90522-9
Diane E. Matthew, J.Brian Houston, Drug metabolizing capacity in vitro and in vivo—I: Correlations between hepatic microsomal monooxygenase markers in β-naphthoflavone-induced rats Biochemical Pharmacology. ,vol. 40, pp. 743- 749 ,(1990) , 10.1016/0006-2952(90)90310-H
S D Hall, F P Guengerich, G R Wilkinson, R G Knodell, Hepatic metabolism of tolbutamide: characterization of the form of cytochrome P-450 involved in methyl hydroxylation and relationship to in vivo disposition. Journal of Pharmacology and Experimental Therapeutics. ,vol. 241, pp. 1112- 1119 ,(1987)
Yuan-Ying Pei, Meir Bialer, René H. Levy, Effects of phenobarbital steady state levels on antipyrine clearance and distribution in the rat. Biopharmaceutics & Drug Disposition. ,vol. 7, pp. 11- 19 ,(1986) , 10.1002/BDD.2510070103
Sammye L. Newman, Philip S. Guzelian, Identification of the cyanopregnenolone-inducible form of hepatic cytochrome P-450 as a catalyst of aldrin epoxidation Biochemical Pharmacology. ,vol. 32, pp. 1529- 1531 ,(1983) , 10.1016/0006-2952(83)90477-X
Takashi MATSUBARA, Emiko YOSHIHARA, Tsuyoshi IWATA, Yoshihiro TOCHINO, Yoshimi HACHINO, BIOTRANSFORMATION OF COUMARIN DERIVATIVES (1) 7-ALKOXYCOUMARIN O-DEALKYLASE IN LIVER MICROSOMES Japanese Journal of Pharmacology. ,vol. 32, pp. 9- 21 ,(1982) , 10.1254/JJP.32.9