Biogenesis and secretion of overproduced protein in recombinant strains of Escherichia coli
作者： A.O. Badyakina , M.A. Nesmeyanova
DOI: 10.1016/J.PROCBIO.2004.02.012
关键词: Gene 、 Secretion 、 Biology 、 Cell envelope 、 Secretory protein 、 Plasmid 、 Biochemistry 、 Recombinant DNA 、 Escherichia coli 、 Biogenesis
摘要: Abstract Recombinant bacterial strains with the genes of proteins interest cloned in plasmids provide an oversynthesis these proteins, which is important for their large-scale production. However, enhanced synthesis protein accompanied by changes its biogenesis and accumulation intermediate forms corresponding to different steps posttranslational modification, as well a change localization. This review surveys peculiarities localization secreted produced recombinant example Escherichia coli alkaline phosphatase (PhoA). They might be interesting researchers studying fundamental applied aspects E. strains.
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