Insulin-Sensitizer Effects of Fenugreek Seeds in Parallel with Changes in Plasma MCH Levels in Healthy Volunteers.

摘要: In developed, developing and low-income countries alike, type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases, severity which substantially a consequence multiple organ complications that occur due to long-term progression disease before diagnosis treatment. Despite enormous investment into characterization disease, its management remains problematic, with those afflicted enduring significant degradation in quality-of-life. Current research efforts etiology pathogenesis T2DM, are focused on defining aberrations cellular physiology result development insulin resistance strategies for increasing sensitivity, along downstream effects T2DM pathogenesis. Ongoing use plant-derived naturally occurring materials delay onset or alleviate symptoms viewed by clinicians as particularly desirable well-established efficacy minimal toxicity such preparations, generally lower per-patient costs, comparison many modern pharmaceuticals. A attractive candidate this respect, fenugreek, plant has been used flavouring human diet through recorded history. The present study assessed insulin-sensitizing effect fenugreek seeds cohort volunteers, tested hypothesis melanin-concentrating hormone (MCH) acts critical determinant effect. test was undertaken using hyperinsulinemic euglycemic glucose clamp approach assess sensitivity response oral administration seed preparation healthy subjects. Outcomes these evaluations demonstrated improvement tolerance, especially patients impaired responses. Outcome data further suggested intake-mediated correlated reduction MCH levels.