Role of Suppressive Oral Antibiotics in Orthopedic Hardware Infections for Those Not Undergoing Two-Stage Replacement Surgery.

摘要: Background. The use of suppressive antibiotics in treatment orthopedic hardware infections (OHIs), including spinal infections, prosthetic joint and internal fixation devices, is controversial. Methods. Over a 4-year period at 2 academic medical centers, patients with OHI who were treated debridement retention components, single-stage exchange, or without surgery studied to determine whether oral for least 6 months after diagnosis impacts successful the infection 1 year diagnosis. Results. Of 89 study, 42 (47.2%) free clinical initial diagnosis. Suppressive used was not associated being (adjusted odds ratio [aOR], 5.29; 95% confidence interval [CI], .74–37.80), but on 3 (OR, 3.50; CI, 1.30–9.43). Causative organisms impacted likelihood success; methicillin-resistant Staphylococcus aureus as well Gram-negative rods both less likely have achieved success (aOR = 0.018, CI .0017–.19 aOR 0.20, .039–.99, respectively). Conclusions. Oral antibiotic therapy months, postdiagnosis increases success. The implicated directly impact