Risk of Fracture after Androgen Deprivation for Prostate Cancer
作者： Vahakn B. Shahinian , Yong-Fang Kuo , Jean L. Freeman , James S. Goodwin
DOI: 10.1056/NEJMOA041943
关键词: Androgen 、 Cancer 、 Internal medicine 、 Risk factor 、 Epidemiology 、 Prostate cancer 、 End results 、 Medicine 、 Osteoporosis 、 Surgery 、 Proportional hazards model
摘要: Background The use of androgen-deprivation therapy for prostate cancer has increased substantially over the past 15 years. This treatment is associated with a loss bone-mineral density, but risk fracture after not been well studied. Methods We studied records 50,613 men who were listed in linked database Surveillance, Epidemiology, and End Results program Medicare as having received diagnosis period from 1992 through 1997. primary outcomes occurrence any resulting hospitalization. Cox proportional-hazards analyses adjusted characteristics patients cancer, other received, or osteoporosis during 12 months preceding cancer. Of surviving at least five years diagnosis, 19.4 percent those therapy...
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