Diffuse Noxious Inhibitory Controls in Anti-Nociception Produced by Acupuncture and Moxibustion on Trigeminal Caudalis Neurons in Rats
作者： Kentaro Murase , Kenji Kawakit
关键词: Physical Stimulation 、 Receptive field 、 Moxibustion 、 Acupuncture 、 Diffuse noxious inhibitory control 、 Anesthesia 、 Nociception 、 Nociceptor 、 Stimulation 、 Pharmacology 、 Medicine
摘要: Numerous studies have demonstrated that acupuncture and moxibustion induce analgesic effects. This study examined whether diffuse noxious inhibitory controls (DNIC) participated in induced-analgesia. Single unit extracellular recordings from neurons the trigeminal nucleus caudalis of urethane-anesthetized Wistar rats were obtained with a glass micropipette. A total 52 single units, including 36 wide dynamic range (WDR), 5 nociceptive specific (NS) 11 low-threshold mechanoreceptive (LTM) units examined. During test stimulation (cutaneous pinch or electrical stimulation), acupuncture, was applied as conditioning stimulus to remote area receptive fields. When induced rapid suppression field response, examination revealed various areas entire body affected increased an intensity-dependent manner. These features resemble DNIC phenomena. The observed on both WDR NS but not LTM neurons. Eight 16 inhibited by five 14 moxibustion, seventeen 21 pinching stimulation. Of neurons, one 2 suppressed two 3 Pinch most profound followed manual acupuncture. Moxibustion moderate long induction time. results suggest may be involved mechanism moxibustion.
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