Role of Gag and lipids during HIV-1 assembly in CD4+ T cells and macrophages

摘要: HIV-1 is an RNA enveloped virus that preferentially infects CD4+ T lymphocytes and also macrophages. In cells, mainly buds from the host cell plasma membrane. The viral Gag polyprotein targets membrane orchestrator of HIV assembly as its expression sufficient to promote formation virus-like particles carrying a lipidic envelope deriving Certain lipids are enriched in thought play key role process envelop composition. A large body work performed on infected cells has provided important knowledge about lipid While budding macrophages follow same general Gag-driven mechanism T-lymphocytes, cycle macrophage exhibits specific features. these new virions bud limiting seemingly intracellular compartments, where they accumulate while remaining infectious. These structures now often referred Virus Containing Compartments (VCCs). Recent studies suggest VCCs represent intracellularly sequestered regions membrane, but their precise nature remains elusive. proteomic lipidomic characterization produced by or highlighted similarity between composition producer well enrichment acidic lipids, some components raft tetraspanin-enriched microdomains. Great chances promotes coalescence into platform which takes place. How exactly interacts with what mechanisms involved interaction different nanodomains within unclear. Here we review recent literature regarding