97 – The Relationship Between Obesity and Alcoholic Pathology

摘要: This chapter discusses the relationship between obesity and alcohol induced pathology. Obese alcoholics have a higher risk of developing alcoholic liver disease. nonalcoholic subjects can develop steatohepatitis, whose pathological features are indistinguishable from It is thus inferred that obese share metabolic alterations causing damage. Fatty infiltration liver, caused by or obesity, increase oxidative stress cause mitochondrial dysfunction. Cytochrome P 450 2E 1 both in individuals alcoholics. Adipose tissue activated Kupfer cells synthesize tumor necrosis factor, which may contribute to Folate deficiency, hyperhomocysteinemia, consequential defect methylation reactions also occur subjects. Betaine, methyl donor, minimize damage mice. In humans with disease, S-adenosyl- methionine reduces mortality need for transplantation.