Experimental hypergammaglobulinemia in mink.

摘要: Hypergammaglobulinemia in mink was produced by the injection of crude tissue suspensions from with spontaneous Aleutian disease. The initiating factor found to be resistant 0.3 per cent formalin for 2 weeks but not 40 at 5°C. Foreign antigens as well formalinized normal homologous and heterologous genotypes did cause a detectable change serum protein values. Mink homozygous recessive gene were significantly more susceptible experimental disease. Possible pathogenetic mechanisms similarities between disease certain immunologic connective diseases man are discussed.