Aldosterone and left ventricular hypertrophy in Afro-Caribbean subjects with low renin hypertension.
作者： A STEWART , S MILLASSEAU , M DAWES , P KYD , J CHAMBERS
DOI: 10.1016/J.AMJHYPER.2005.06.035
关键词: Interquartile range 、 Medicine 、 Mineralocorticoid 、 Aldosterone 、 Plasma renin activity 、 Internal medicine 、 Morning 、 Blood pressure 、 Cardiology 、 Left ventricular hypertrophy 、 Renin–angiotensin system 、 Endocrinology
摘要: Background Activity of the renin-angiotensin-aldosterone system is thought to play a major role in determining blood pressure (BP) and target organ damage such as left ventricular hypertrophy. In Afro-Caribbean subjects, however, hypertension tends be more severe despite lower plasma renin activity. We investigated whether this might due different relation between aldosterone compared white subjects. Methods Plasma activity were assessed morning after 15 min seated 383 hypertensive subjects or ethnicity (61% Afro-Caribbean, 83% on treatment) attending clinic London, UK. Left mass index (LVMI) was by echocardiography 276 Results (0.4 [0.3–1.0] v 1.4 [0.5–3.4] ng/mL/h, medians [interquartile range], P 7.4 [2.3–17.1] ng/dL, Conclusions elevated may contribute increased severity hypertrophy
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