Central nervous system stimulants: basic pharmacology and relevance to anaesthesia and critical care

摘要: Abstract Central nervous system (CNS) stimulants are common in clinical practice, and have a high potential for abuse. The CNS can be classified as analeptic stimulants, psychomotor or methylxanthines. Doxapram activates peripheral chemoreceptors central respiratory centres dose-dependent manner. Psychomotor (e.g. cocaine amfetamines) increase sympathetic activity. Competition various metabolic transport processes lead to dangerous drug interactions. Sympathomimesis the perioperative period may result haemodynamic instability, cardiac dysrhythmias, myocardial ischaemia. Therapeutic methylxanthines used mainly stimulate centres.