Pharmacogenomics in osteoporosis: Steps toward personalized medicine

摘要: Osteoporosis is a complicated and preventable disease with major morbidity complications that affects millions of people. In the last 15 years, there have been numerous studies research in new fields pharmacogenetics pharmacogenomics related to osteoporosis. Numerous “candidate genes” identified found be associated osteoporosis as well treatment Many conflicting results on different polymorphisms whether or not they are bone mineral density There need for larger better designed pharmacogenomic incorporating greater variety candidate genes. The evaluation fracture risk moving from stratification approach more individualized approach, which an individual’s absolute evaluable constellation environmental exposure genetic makeup. Therefore, identification gene variants phenotypes response therapy might help individualize prognosis, treatment, prevention fracture. This review focuses genes what needs done take genetics incorporate them into management