Si nanowires forest-based on-chip biomolecular filtering, separation and preconcentration devices: nanowires do it all.

摘要: The development of efficient biomolecular separation and purification techniques is critical importance in modern genomics, proteomics, biosensing areas, primarily due to the fact that most biosamples are mixtures high diversity complexity. Most existent lack capability rapidly selectively separate concentrate specific target proteins from a complex biosample, difficult integrate with lab-on-a-chip sensing devices. Here, we demonstrate an on-chip all-SiNW filtering, selective separation, desalting, preconcentration platform for direct analysis whole blood other biosamples. required protein analytes raw first performed using antibody-modified roughness-controlled SiNWs (silicon nanowires) forest ultralarge binding surface area, followed by release controlled liquid media, their subsequent detection supersensitive SiNW-based FETs arrays ...