HLA‐B*27:04 associated with enthesitis and younger age of onset, and HLA‐B allele profile in patients with ankylosing spondylitis in Thailand: A cross‐sectional study

摘要: AIM The aims of this study were to estimate human leukocyte antigen (HLA)-B allele frequency, identify alleles associated with ankylosing spondylitis (AS), and explore manifestations in various HLA-B*27 Thai AS patients. METHODS This was a cross-sectional study. patients older than 18 years diagnosed according modified New York criteria who visited Siriraj Hospital (Bangkok, Thailand) consecutively enrolled. HLA-B determined by reverse sequence-specific oligonucleotide assays, assigned at 4-digit resolution. 334 unrelated healthy donors participated previous phase 2b dengue vaccine clinical trial included as controls. Odds ratio (OR) Fisher's exact test used association between AS. P value significance threshold calculated Bonferroni. RESULTS Among the 88 recruited, 34 identified, all heterozygous. prevalence 89.8%, 4 identified. HLA-B*27:04 (OR: 39.4, P < .0001) HLA-B*27:05 13.8, P = .0011) In contrast, HLA-B*27:06 not found be 0.4, P = .241). carrying more likely have enthesitis younger age onset those HLA-B*27:05. CONCLUSIONS both strongly showed neutral for had