MicroRNA dysregulation in uveal melanoma: a new player enters the game

作者: Zheng Li , Xin Yu , Jianxiong Shen , Yang Jiang

DOI: 10.18632/ONCOTARGET.2923

关键词: EpigeneticsmicroRNAUveal NeoplasmMelanomaDiseaseCancer researchMetastasisNon-coding RNAImmunologyMedicineOncogene

摘要: // Zheng Li 1, * , Xin Yu Jianxiong Shen 1 Yang Jiang 2 Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy Sciences and College, Beijing 100730, China Ophthalmology, These authors have contributed equally to this work Correspondence to: Shen, e-mail: shenjianxiong@medmail.com.cn Keywords: Uveal melanoma, microRNAs, diagnosis therapy, oncogene, tumor suppressor Received: November 25, 2014      Accepted: December 15, Published: January 27, 2015 ABSTRACT melanoma is the second most common form a predominant intraocular malignant in adults. The development uveal multistep process involving genetic epigenetic alteration proto-oncogenes tumor-suppressor genes. Recent discoveries shed new light on involvement class noncoding RNA known as microRNAs (miRNAs) melanoma. A lot miRNAs show differential expressions tissues cell lines. Genes coding for these been characterized novel oncogene genes based findings that control phenotypes cells. Several studies confirmed dysregulation promotes cell-cycle progression, confers resistance apoptosis, enhances invasiveness metastasis. Moreover, several also shown correlate with initiation thus may be used biomarkers early prognosis. Elucidating biological aspects miRNA help us better understand pathogenesis promote directed-therapeutics against disease.

参考文章(47)
Krishna K. Banaudha, Mukesh Verma, The role of microRNAs in the management of liver cancer. Methods of Molecular Biology. ,vol. 863, pp. 241- 251 ,(2012) , 10.1007/978-1-61779-612-8_14
Konstantinos G. Sidiropoulos, Nicole M.A. White, Anna Bui, Qiang Ding, Peter Boulos, Georgios Pampalakis, Heba Khella, Joseph N. Samuel, Georgia Sotiropoulou, George M. Yousef, Kallikrein-related peptidase 5 induces miRNA-mediated anti-oncogenic pathways in breast cancer. Oncoscience. ,vol. 1, pp. 709- 724 ,(2014) , 10.18632/ONCOSCIENCE.91
Kristina Buder, Anja Gesierich, Götz Gelbrich, Matthias Goebeler, Systemic treatment of metastatic uveal melanoma: review of literature and future perspectives Cancer Medicine. ,vol. 2, pp. 674- 686 ,(2013) , 10.1002/CAM4.133
Jason J. Luke, Margaret K. Callahan, Michael A. Postow, Emanuela Romano, Nikhil Ramaiya, Mark Bluth, Anita Giobbie-Hurder, Donald P. Lawrence, Nageatte Ibrahim, Patrick A. Ott, Keith T. Flaherty, Ryan J. Sullivan, James J. Harding, Sandra D'Angelo, Mark Dickson, Gary K. Schwartz, Paul B. Chapman, Jedd D. Wolchok, F. Stephen Hodi, Richard D. Carvajal, Clinical activity of ipilimumab for metastatic uveal melanoma: a retrospective review of the Dana-Farber Cancer Institute, Massachusetts General Hospital, Memorial Sloan-Kettering Cancer Center, and University Hospital of Lausanne experience. Cancer. ,vol. 119, pp. 3687- 3695 ,(2013) , 10.1002/CNCR.28282
Zhiyu Wang, Neng Wang, Pengxi Liu, Qianjun Chen, Honglin Situ, Ting Xie, Jianxing Zhang, Cheng Peng, Yi Lin, Jianping Chen, MicroRNA-25 regulates chemoresistance-associated autophagy in breast cancer cells, a process modulated by the natural autophagy inducer isoliquiritigenin Oncotarget. ,vol. 5, pp. 7013- 7026 ,(2014) , 10.18632/ONCOTARGET.2192
H. Ohdaira, M. Sekiguchi, K. Miyata, K. Yoshida, MicroRNA‐494 suppresses cell proliferation and induces senescence in A549 lung cancer cells Cell Proliferation. ,vol. 45, pp. 32- 38 ,(2012) , 10.1111/J.1365-2184.2011.00798.X
Yevgeniy Shildkrot, Fridtjof Thomas, Adham Al-Hariri, Constance L. Fry, Barrett G. Haik, Matthew W. Wilson, Socioeconomic factors and diagnosis of uveal melanoma in the mid-southern United States. Current Eye Research. ,vol. 36, pp. 824- 830 ,(2011) , 10.3109/02713683.2011.593109
S E Coupland, S L Lake, M Zeschnigk, B E Damato, Molecular pathology of uveal melanoma Eye. ,vol. 27, pp. 230- 242 ,(2013) , 10.1038/EYE.2012.255
Paula L. Blanco, Li Anne Lim, Cristina Miyamoto, Miguel N. Burnier, Uveal melanoma dormancy: an acceptable clinical endpoint? Melanoma Research. ,vol. 22, pp. 334- 340 ,(2012) , 10.1097/CMR.0B013E328357BEA8
Han-Shao Liu, MicroRNAs as potential biomarkers for gastric cancer World Journal of Gastroenterology. ,vol. 20, pp. 12007- 12017 ,(2014) , 10.3748/WJG.V20.I34.12007