Consequences of hyperoxia and the toxicity of oxygen in the lung.

摘要: Oxygen (O2) is life essential but as a drug has maximum positive biological benefit and accompanying toxicity effects. therapeutic for treatment of hypoxemia hypoxia associated with many pathological processes. Pathophysiological processes are increased levels hyperoxia-induced reactive O2 species (ROS) which may readily react surrounding tissues, damaging lipids, proteins, nucleic acids. Protective antioxidant defenses can become overwhelmed ROS leading to oxidative stress. Activated alveolar capillary endothelium characterized by adhesiveness causing accumulation cell populations such neutrophils, source ROS. Increased cause hyperpermeability, coagulopathy, collagen deposition well other irreversible changes occurring within the space. In hyperoxia, multiple signaling pathways determine pulmonary cellular response: apoptosis, necrosis, or repair. Understanding effects administration important prevent inadvertent damage caused hyperoxia in patients requiring supplemental oxygenation.