Doxorubicin loading fucoidan acetate nanoparticles for immune and chemotherapy in cancer treatment.
作者： Kun Woo Lee , Dooyong Jeong , Kun Na
DOI: 10.1016/J.CARBPOL.2013.02.018
关键词: Drug carrier 、 Pharmacology 、 Fucoidan 、 Multiple drug resistance 、 Tumor necrosis factor alpha 、 Chemotherapy 、 Doxorubicin 、 Chemistry 、 Drug resistance 、 IC50
摘要: In order to develop immuno- and chemotherapy agents, self-organized acetylated fucoidan (AcFu) nanoparticles were designed. Doxorubicin (DOX), used as a model drug, was loaded into the AcFu by dialysis. The DOX loading efficacy content 71.1% 3.6%, respectively. Approximately 140 nm of spherical obtained. DOX-loaded (DOX-AcFu) exhibited first-order drug release behavior for 5 days. Interestingly, treated Raw264.7 macrophages overexpressed various anti-tumor cytokines, such tumor necrosis factor-alpha (TNF-α) granulocyte-macrophage colony-stimulating factor (GM-CSF). ability DOX-AcFu suppress efflux revealed confocal microscope images FACS analysis in multidrug resistance (MDR) cells. IC50 (50% inhibitory concentration) value lower than that free MDR Based on these results, we strongly suggest have promising potential development one-step therapy containing agents both chemotherapy.
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