Albumin variants and conjugates
作者： Esben Peter Friis , Jason Cameron , Joanna Mary Hay , Darrell Sleep , Christopher John Arthur Finnis
DOI:
关键词: Bioactive compound 、 Albumin 、 Cysteine 、 Residue (chemistry) 、 Biochemistry 、 Conjugate 、 Conjugated system 、 Free thiol 、 Chemistry 、 Stereochemistry
摘要: Based on the three-dimensional structure of albumin, inventors have designed variant polypeptides (muteins) which one or more cysteine residues with a free thiol group (hereinafter referred to as “thio-albumin”). The polypeptide may be conjugated through sulphur atom residue conjugation partner such bioactive compound.
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