Control of vascular responsiveness during human pregnancy

摘要: Over 40 years ago, Dieckmann and Michel reported that vascular reactivity to the pressor effects of a vasoactive agent (crude vasopressin) is greater in preeclamptic than normotensive pregnant women [1]. In 1956, Raab et al found similar responses infusion catecholamines [2]. Neither these groups investigators significant difference response between nonpregnant subjects normal controls. 1961, however, Abdul-Karim Assali standard dose angiotensin II (AII) late pregnancy was much less observed after delivery; is, were relatively refractory infused AII [3]. 1968, Talledo, Chesley, Zuspan as sensitive AH subjects. The appeared have lost their pregnancy-associated refractoriness [4]. These authors conjectured relative occurred might be consequence an elevated plasma concentration AII. Notably, injected exhibited by patients with secondary aldosteronism congestive heart failure or cirrhosis ascites [5, 6].