Electrochemical behavior of ellipticine derivatives: Part IV. Oxidation of a series of variously substituted ellipticine derivatives

作者: J. Moiroux , A.M. Armbruster

DOI: 10.1016/S0022-0728(84)80100-X

关键词: Transition metalPyridineEllipticinesMedicinal chemistryProtonationChemistryElectrochemistryAqueous solutionBasic solutionOrganic chemistryAcetonitrile

摘要: Abstract An electrochemical approach was used in order to study the 1 e − oxidation of a series hydroxy-ellipticinium cations (i.e. where nitrogen pyridine ring is protonated) aqueous acid media and 2 same hydroxy-ellipticines basic media. The ellipticines without hydroxy substituents accompanied with moderately fast dimerization also occurs acetonitrile.

参考文章(13)
C.P. Andrieux, J.M. Savéant, Electrodimerization: II. Reduction mechanism of immonium cations Journal of Electroanalytical Chemistry. ,vol. 26, pp. 223- 235 ,(1970) , 10.1016/S0022-0728(70)80307-2
J. F. Ambrose, R. F. Nelson, Anodic Oxidation Pathways of Carbazoles I . Carbazole and N‐Substituted Derivatives Journal of The Electrochemical Society. ,vol. 115, pp. 1159- 1164 ,(1968) , 10.1149/1.2410929
B. Festy, J. Poisson, C. Paoletti, A new DNA intercalating drug: Methoxy-9-ellipticine FEBS Letters. ,vol. 17, pp. 321- 323 ,(1971) , 10.1016/0014-5793(71)80176-X
Jean-Yves Lallemand, Pierre Lemaitre, Lee Beeley, Pierre Lesca, Daniel Mansuy, Hydroxylation de l'ellipticine chez le rat: structure des deux principaux métabolites. Synthèse de l'hydroxy-7 ellipticine Tetrahedron Letters. ,vol. 19, pp. 1261- 1264 ,(1978) , 10.1016/0040-4039(78)80101-4
J.C. Imbeaux, J.M. Savéant, Linear sweep voltammetry. Effect of uncompensated cell resistance and double layer charging on polarization curves Journal of Electroanalytical Chemistry. ,vol. 28, pp. 325- 338 ,(1970) , 10.1016/S0022-0728(70)80127-9
Christian Auclair, Claude Paoletti, Bioactivation of the antitumor drugs 9-hydroxyellipticine and derivatives by a peroxidase-hydrogen peroxide system Journal of Medicinal Chemistry. ,vol. 24, pp. 289- 295 ,(1981) , 10.1021/JM00135A010