Radiofrequency ablation of hepatocellular cancer in 110 patients with cirrhosis.

摘要: Hepatocellular carcinoma (HCC) is a common cause of death in patients with cirrhosis. Cirrhosis develops as result chronic liver injury secondary to extrinsic environmental factors the vast majority affected individuals. Hepatitis B or C virus infection, aflatoxin B1 other mycotoxin ingestion, and prolonged ethanol abuse are major causes 1 The worldwide population at risk for developing HCC because one more these etiologic numbers tens millions: United States Italy, example, there an estimated 7.5 million persons hepatitis infection. 2,3 In most HCC, treatment options limited by dysfunction caused inflammation Although complete surgical resection offers best chance long-term survival, cirrhosis may limit amount parenchymal that will be tolerated increases postoperative failure death. 4–6 Systemic regional chemotherapy palliative small subset (although rarely have sufficient tumor downstaging convert unresectable resectable lesion), but cost significant side effects reduced quality life. In confined liver, not safe, local tumor-ablation therapies considered alternative options. Radiofrequency ablation (RFA) thermal technique designed produce localized destruction heating tissue temperatures exceed 50°C. When cells heated above 45° 50°C than 3 minutes, intracellular protein denaturation melting lipid bilayers results direct cell 7–10 RFA uses alternating current passed across needle electrode arrays placed directly into tumor. Ionic stimulation induced surrounding array produces gradual frictional heating, rise 80° 110°C, which coagulative necrosis proximity electrode. basic principle similar electrocautery units used achieve intraoperative hemostasis. We performed this prospective study using treat determine efficacy, safety, control, patterns failure, treatment-related complications.