Seizure frequency, patient-perceived seizure severity and the psychosocial consequences of intractable epilepsy

摘要: It is generally recognised that the assessment of treatment effects in epilepsy using seizure frequency as only outcome measure may lack sensitivity. A patient-based severity scale has been developed and initial results confirm its reliability validity. As part further development this it important to explore relationship between severity, psychosocial consequences intractable epilepsy. One hundred patients with medically refractory partial seizures completed a quality life questionnaire including measures physical (seizure frequency), social psychological well-being (anxiety, depression, self-esteem, locus control happiness). Multivariate analysis demonstrated individual variables were best predicted by other variables. However, when these removed from analysis, was most significant predictor self-esteem (P = 0.005), P 0.039) anxiety 0.048). Seizure did not contribute significantly variance any factors. These highlight importance considering assessing provide evidence for construct validity novel scale.