Inhibition of translation by RNA-small molecule interactions.

作者： ISABELLE HARVEY , PHILIPPE GARNEAU , JERRY PELLETIER

DOI: 10.1017/S135583820202633X

关键词: Gene expression 、 Ribosome assembly 、 Cell biology 、 RNA 、 Eukaryotic Ribosome 、 Untranslated region 、 Small molecule 、 Molecular biology 、 Biology 、 Messenger RNA 、 Translation (biology)

摘要: … to the number of binding sites within this region. We find that small molecule ligand–RNA interactions can be sufficiently stable to prevent 80S ribosome assembly on an mRNA …