Gene therapy for established murine collagen-induced arthritis by local and systemic adenovirus-mediated delivery of interleukin-4
作者： Seon Hee Kim , Christopher H Evans , Sunyoung Kim , Thomas Oligino , Steven C Ghivizzani
DOI: 10.1186/AR104
关键词: Pathology 、 Inflammation 、 Ankle 、 Internal medicine 、 Arthritis 、 Rheumatoid arthritis 、 Immunology 、 Interleukin 10 、 Rheumatology 、 Genetic enhancement 、 Interleukin 4 、 Medicine
摘要: To determine whether IL-4 is therapeutic in treating established experimental arthritis, a recombinant adenovirus carrying the gene that encodes murine (Ad-mIL-4) was used for periarticular injection into ankle joints mice with collagen-induced arthritis (CIA). Periarticular of Ad-mIL-4 resulted reduction severity and joint swelling compared saline- adenoviral control groups. Local expression also reduced macroscopic signs inflammation bone erosion. Moreover, hind decrease disease untreated front paws. Systemic delivery by intravenous significant early-stage arthritis.
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