作者: M. P. Wattjes , M. D. Steenwijk , M. Stangel
DOI: 10.1007/S00062-015-0430-Y
关键词: Neurosurgery 、 Safety monitoring 、 Review article 、 Progressive multifocal leukoencephalopathy 、 Surgery 、 Magnetic resonance imaging 、 Neuroradiology 、 Medicine 、 Intensive care medicine 、 Multiple sclerosis 、 Neurology
摘要: Magnetic resonance imaging (MRI) is the most powerful tool for early (differential) diagnosis of multiple sclerosis (MS) and has been part International Panel criteria (2001, 2005, 2010) more than 10 years. The role brain spinal cord MRI in MS well established. New MR techniques markers will further improve diagnostic value a research clinical routine setting. In addition to diagnosis, widely used prognostic evaluation as treatment efficacy safety monitoring. This field gained importance with introduction new therapeutics. Therefore, scope MRI-guided disease monitoring widened include rigorous aiming at “no evidence activity (NEDA)”. Next, treated patients become major concern enable detection opportunistic infections such progressive multifocal leukoencephalopathy (PML). Driven by these developments, recently published expert panel guidelines stressed need standardized protocols targeted specialized review article aims give an update on particular emphasis safety, both practice research.