Influence of H. pylori Infection on gastric motor and sensory function in asymptomatic volunteers

作者: Stuart B. Saslow , Miriam Thumshirn , Michael Camilleri , G. Richard III Locke , George M. Thomforde

DOI: 10.1023/A:1018833701109

关键词: Gastric emptyingStomachHepatologyInternal medicineAsymptomaticBarostatGastroenterologyHelicobacter pyloriMedicinePostprandialGastritis

摘要: The effect of H. pylori infection on gastricmotility and sensation is unclear. Our hypothesis isthat increases gastric andreduces accommodation emptying. In eight pylori-positive H.pylori-negative asymptomatic subjects, wasproven by antral histology or culture. We evaluated: (1)gastric emptying solids, (2) proximal gastriccompliance, (3) fasting postprandial gastrictone phasic contractions, (4) sensationduring balloon inflations ingestion cold water,and (5) abdominal vagal function. was associated with lower accommodation(median 75% increase in barostat balloonvolume compared to fasting) when theaccommodation uninfected volunteers (median 211% change from fasting). One pylori-positivesubject had an abnormal function testand her response reduced.Other motor sensory functions the two groups were similar. volunteers, H.pylori gastritis result reducedaccommodation (diastolic dysfunction) but no inoverall thestomach.

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