Multiple Neurodegenerative Pathologies in an Alzheimer's Disease Patient Treated with Fornical Deep Brain Stimulation.
作者： Constantine G Lyketsos , Liam Chen , Paul B Rosenberg , Bartholomew White , Esther S Oh
DOI: 10.3233/JAD-201415
关键词: Tauopathy 、 Disease 、 Neuroscience 、 Movement disorders 、 Alpha-synuclein 、 Deep brain stimulation 、 Cognitive decline 、 Fornix 、 Medicine 、 Autopsy
摘要: As an established treatment for movement disorders, deep brain stimulation (DBS) has been adapted the of Alzheimer's disease (AD) by modulating fornix activity. Although it is generally regarded as a safe intervention in patients over 65 years age, complex neurophysiology and interconnection within circuits connected to warrants careful ongoing evaluation true benefit risk potential DBS on slowing cognitive decline AD patients. Here we report patient who died long after being implanted with device donated her neuropathologic study. The autopsy confirmed multiple proteinopathies including AD-related change, diffuse neocortical Lewy body disease, TDP-43 proteinopathy, nonspecific tauopathy. We discuss possible mechanisms these overlapping neurodegenerative disorders caution that future studies will need take findings into consideration.
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