Ciclosporin use in acute ulcerative colitis: a long-term experience.

摘要: BACKGROUND: Within a lifetime, approximately 15% of ulcerative colitis (UC) patients will have severe relapse necessitating admission to hospital. Despite intravenous steroid treatment, 25% require either surgery or ciclosporin (CsA) rescue therapy. Initial response rates CsA been encouraging, but remission disappointing. There is paucity long-term data on UC who brought into with CsA. OBJECTIVES: To report our 7 year experience the use in acute and highlight follow-up these patients. PATIENTS AND METHODS: A retrospective database 76 requiring between 1996 2003 was constructed. started basis their C-reactive protein (CRP) and/or stool frequency after 3 days 5-7 i.v. hydrocortisone. The (33 female, 43 male, mean age 44.5 years) were followed up for median 2.9 years (range 0.2-7.0 years). Fifty-four received (4 mg/kg), while 22 oral (5 mg/kg). Long-term outcome evaluated by Kaplan-Meier survival analysis: time first surgery. RESULTS: Median disease duration 6.6 years. CRP at day 20 mg/l 6 per day, respectively. Fifty-six (74%) achieved initial remission. discontinued only four due side effects. Duration steroids addition AZA did not improve Comparison revealed statistically significant difference (P < 0.01) 0.05) favour CONCLUSIONS: These describe largest series so far reported that had treatment refractory UC. If CsA, 1 year, 65% relapsed 90% relapsed. After years, 58% come colectomy. Minor effects frequent, none life threatening. no increase post-operative complications those came