Alternative splicing of the rat Cav3.3 T-type calcium channel gene produces variants with distinct functional properties1
作者： Janet Murbartián , Juan Manuel Arias , Jung-Ha Lee , Juan Carlos Gomora , Edward Perez-Reyes
DOI: 10.1016/S0014-5793(02)03341-0
关键词: Biology 、 splice 、 Gene 、 RNA splicing 、 Genetics 、 Exon 、 Minigene 、 T-type calcium channel 、 Alternative splicing 、 Exonic splicing enhancer
摘要: Molecular diversity in T-type Ca2+ channels is produced by expression of three genes, and alternative splicing those genes. Prompted differences noted between rat human Cav3.3 sequences, we searched for splice variants. We cloned six variants, which are at exon 33 34. Expression the variants differed brain regions. The electrophysiological properties displayed similar voltage-dependent gating, but their kinetic properties. functional impact was inter-related, suggesting an interaction. conclude that gene produces with distinct
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