Zeb2 drives invasive and microbiota-dependent colon carcinoma

摘要: Colorectal cancer (CRC) is highly prevalent in Western society, and increasing evidence indicates strong contributions of environmental factors the intestinal microbiota to CRC initiation, progression even metastasis. We have identified a synergistic inflammatory tumor-promoting mechanism through which resident boosts invasive development an epithelial-to-mesenchymal transition-prone tissue environment. Intestinal epithelial cell (IEC)-specific transgenic expression transition regulator Zeb2 mice (Zeb2IEC-Tg/+) leads increased permeability, myeloid cell-driven inflammation spontaneous development. Zeb2IEC-Tg/+ develop dysplastic colonic epithelium, progresses severely inflamed neoplastic lesions while small epithelium remains normal. are characterized by dysbiosis, depletion with broad-spectrum antibiotics or germ-free rederivation completely prevents represent first mouse model microbiota-dependent will help us better understand host–microbiome interactions driving humans. Van Loo colleagues report that loss from inflammation, permeability colorectal development, enhanced microbiome.