Correlations between transmural mechanical and morphological properties in porcine thoracic descending aorta

摘要: Determination of correlations between transmural mechanical and morphological properties aorta would provide a quantitative baseline for assessment preventive therapeutic strategies aortic injuries diseases. A multimodal multidisciplinary approach was adopted to characterize the descending porcine aorta. Histology multi-photon microscopy were used describing media layer micro-architecture in circumferential-radial plane, Fourier Transform infrared imaging spectroscopy utilized determining structural protein, total protein content. The distributions these quantified across thickness characterized their relationship with from previous study determined. Our findings indicate that there is an increasing trend instantaneous Young׳s modulus (E), elastic lamella density (ELD), (SPR), (TPR), elastin collagen circumferential percentage (ECP CCP) inner towards outer layers. Two regions equal (inner halves) determined significantly different material properties. results this represent substantial step toward anatomical characterization wall building blocks establishment foundation quantifying role microstructural components on functionality