Metabolic Signatures of Oxidative Stress in the Red Blood Cells: Editorial Commentary.

摘要: This issue of the journal contains an interesting article—“Metabolic Signatures Oxidative Stress and their Relationship with Erythrocyte Membrane Surface Roughness among Workers Manual Material Handling (MMH)”. stress has been a longtime research interest that is yet to be assessed by clinical laboratory for evidence-based practice, because it perceived implicated in virtually every disease or condition. The report surely backing from literature. For instance, oxidative known metabolic signatures,[1,2] which hallmarked glutathione (GSH), as well reactive oxygen species.[3] The concept erythrocyte (EOS) further denotes biomarkers vis-a-vis signatures are detectable red blood cells. Indeed, cardiovascular complications diabetes represent major health problem worldwide, but knowledge progression degree risk prediabetes limited. Significant changes EOS indicators related macrovascular events may underlie development diabetic complications, have consistently reported. speculated emerging indicators, namely, (1) indices EOS, including erythrocyte-reduced GSH, malondialdehyde, associated enzymes; (2) vasculopathy, plasma D-dimer, homocysteine, whole viscosity; (3) dyslipidemia, total cholesterol (TC), high-density lipoprotein (HDL), TC/HDL ratio. Thus, there recognition spectrum profile[3] should narrowed down useful panel tests improve early identification intervention.[4] The present article highlights significant impact on surface cell membranes. While this effect known,[5] probably appreciated apparently healthy individuals suffer damage occupational hazard. authors attempted develop linear model demonstrate how individual marker roughness membrane. It will see corroborative reports exemplify validate model. Further, have, albeit passively, also mentioned phenomenon carriage inside and/or body must means biochemical parameters nanoscale levels follow being hypoxia — e.g., can induce hyperviscosity turn leads sequence reduced flow, less supply, tissue hypoxia. stress-inducing anemia exacerbating iron-deficiency well. would expatiate phenomenon.