Chemical elements and preeclampsia - An overview of current problems, challenges and significance of recent research

摘要: Abstract Objectives Data on the elemental status, redistribution of elements, role occupational exposure and dietary assessment in preeclampsia (PE) are scarce. There many disparities findings essential non-essential elements’ PE. In this article we overview changes content selected elements pregnancy complicated with disorder complex not fully understood etiology. We have focused important limitations highlighted shortcomings research from last ten years period. Methods The Scopus PubMed electronic databases been searched for English-language articles published within time interval 2008–2018, full text available key words “preeclampsia” “chemical element” (i.e. separately: Cd, Pb, As, Ni, Mo, Co, Cr, Mn, Se, I, Fe, Sr, Cu, Zn, Mg, K Na) appearing title, abstract or keywords. Results A total 48 publications were eligible overview. Surprisingly only 4% papers considered environmental exposure, 8%- diet 2 %- comorbid diseases. most papers, was neglected. Meta-analysis possible seven serum (Ca, Zn), two (Se, Zn) plasma. It showed negative shift however several statistically significant. Conlusions data PE chemical yields varied results. Some reasons may be difference duly validated method determination, huge discrepancies study designs. lack detailed description studied control population small number samples constitute common such studies. Many them describe use a single analytical procedure, therefore quality insufficient to obtain reliable history status intake before during is usually examined. Dietary should done at different stages pregnancy, whenever periconceptional period as well. still needs established whether deficiency certain their excess an etiopathogenic factor developmental cause PE, if it serve target actions causal treatment even prevention occurrence disease.