Diet and chemoprevention of colon polyps and colorectal cancer

摘要: Clinical trials in colorectal cancer prevention are based on carcino-genesis research and epidemiologic observations that relate certain macronutrients, micronutrients, non-nutritive factors foods, synthetic chemicals to colon neoplasms. These appear act at various points along the putative normal mucosa adenomatous polyp sequence. This gives an opportunity develop innovative clinical trials, both agent selection use of intermediate markers. now progress employ dietary fiber, a variety vitamins minerals several drugs, especially NSAIDs. Most these as surrogate marker for cancer, thereby reducing trial duration, number subjects required overall expense. paper is brief review basic background their current status. © 1995 Wiley-Liss, Inc.