Yeast and Fungal Prions.
作者： Reed B. Wickner
DOI: 10.1101/CSHPERSPECT.A023531
关键词: Fungal protein 、 Amyloid 、 Yeast 、 Chaperone (protein) 、 RNA 、 Biology 、 Biochemistry 、 DNA 、 Hsp70 、 Fungal prion
摘要: Yeast and fungal prions are infectious proteins, most being self-propagating amyloids of normally soluble proteins. Their effects range from a very mild detriment to lethal, with specific dependent on the prion protein variant ("prion strain"). The Sup35p, Ure2p, Rnq1p in-register, parallel, folded β-sheets, an architecture that naturally suggests mechanism by which can template its conformation, just as DNA or RNA templates sequence. Prion propagation is critically affected array chaperone systems, notably Hsp104/Hsp70/Hsp40 combination, responsible for generating new seeds old filaments. Btn2/Cur1 antiprion system cures [URE3] develop, Ssb blocks [PSI+] generation.
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