Impact of donor-recipient race matching on survival after lung transplantation: analysis of over 11,000 patients.
作者： Jeremiah G. Allen , Eric S. Weiss , Christian A. Merlo , William A. Baumgartner , John V. Conte
DOI: 10.1016/J.HEALUN.2009.06.012
关键词: Retrospective cohort study 、 Hazard ratio 、 Internal medicine 、 Proportional hazards model 、 Cohort study 、 Cohort 、 Donor selection 、 Medicine 、 Survival rate 、 Surgery 、 Transplantation
摘要: Background Few studies have examined the effect of race in lung transplantation (LTx). The United Network for Organ Sharing (UNOS) database provides an opportunity to examine outcomes matching a large cohort patients. Methods We retrospectively reviewed UNOS data 11,323 adults receiving primary LTx (1997 2007). Patients were stratified by donor–recipient and divided into groups specific race. All-cause mortality was with Cox proportional hazards regression incorporating 19 covariates. Short-term (30 days, 90 1 year 2 years) rejection first examined. Results Of patients, 7,414 (65%) matched, including 7,104 (71%) Caucasians, 184 (22%) African Americans, 117 (28%) Hispanics 9 (11%) Asians. During study, 4,862 (43%) patients died. Race decreased 30-day, 90-day, 1-year 2-year unadjusted mortality. risk-adjusted cumulative (hazard ratio 0.88, 95% confidence interval 0.80 0.96, p = 0.006). Kaplan–Meier modeling showed that significantly improved survival. did not impact after LTx. When deaths censored, no longer affected Donor American conferred increased risk death, regardless recipient Conclusions Our study represents largest evaluating resulted improvement long-term This appears manifest years
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