Hemocompatibility of Poly(vinyl alcohol)-Gelatin Core-Shell Electrospun Nanofibers: A Scaffold for Modulating Platelet Deposition and Activation.
作者： Valerie M. Merkle , Daniel Martin , Marcus Hutchinson , Phat L. Tran , Alana Behrens
关键词: Nanofiber 、 Materials science 、 Composite material 、 Fiber 、 Coaxial 、 Gelatin 、 Platelet adhesiveness 、 Polyvinyl alcohol 、 Chemical engineering 、 Platelet activation 、 Vinyl alcohol
摘要: In this study, we evaluate coaxial electrospun nanofibers with gelatin in the shell and poly(vinyl alcohol) (PVA) core as a potential vascular material by determining fiber surface roughness, well human platelet deposition activation under varying conditions. PVA scaffolds had highest roughness (Ra = 65.5 ± 6.8 nm) but lowest (34.2 5.8 platelets) comparison to 36.8 3.0 nm 168.9 29.8 (1 Gel:1 coaxial, Ra 24.0 1.5 150.2 17.4 platelets. 3 37.1 2.8 167.8 15.4 platelets). Therefore, chemical structure of dominated deposition. Due their increased stiffness, rate, rate thrombin formation, fibers. Our studies indicate that mechanical stiffness is dominating factor for depositi...
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