PEGylation for improving the effectiveness of therapeutic biomolecules.

摘要: Proteins have gained an important role in clinical practice, and they are the treatment of choice or even only therapy for several pathologies. Unfortunately, their great potential is often hampered by relevant shortcomings such as immunogenicity fast body clearance. Polymer conjugation, especially with polyethylene glycol (PEG), has emerged a suitable drug delivery solution to address these drawbacks. Furthermore, this technology been found be powerful approach increase general therapeutic efficacy biomolecules. After first PEG-protein derivatives were released, it was clear that wider exploitation PEGylation could reached through thorough development methods conjugation. At moment, different PEG coupling strategies polymers available. The research field very active large effort focused on developing releasable PEGs, which able release conjugated protein. This feature enables recovery protein activity commonly reduced after polymer coupling.