SC-29333: A potent inhibitor of canine gastric secretion
作者： Esam Z. Dajani , Doyle R. Driskill , Robert G. Bianchi , Paul W. Collins , Raphael Pappo
DOI: 10.1007/BF01071862
关键词: Bolus (medicine) 、 Acid output 、 Prostaglandin E1 Analog 、 Secretion 、 Pepsin 、 Gastric secretion 、 Internal medicine 、 Pentagastrin 、 Endocrinology 、 Chemistry 、 Histamine
摘要: The gastric antisecretory effects of SC-29333, a novel prostaglandin E1 analog, were compared to the reference standard PGE1 methyl ester (PGE1ME) in fistula and Heidenhain pouch dogs. Secretion was stimulated submaximally by continuous intravenous infusion either histamine or pentagastrin. Meal-stimulated secretory studies also conducted. SC-29333 effectively inhibited volume, acid output, pepsin secretion, dose-dependent manner. Intravenously (i.v.), found be approximately 30 times more potent than PGE1ME. ranges active i.v. bolus doses for PGE1ME 0.3–3.0 10–30 μg/kg, respectively. Unlike PGE1ME, orally effective at μg/kg considerably better tolerated longer acting doses. It is concluded, therefore, that potent, long-acting, inhibitor secretion dog.
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