Targeting mast cells in gastric cancer with special reference to bone metastases.

摘要: Bone metastases from gastric cancer (GC) are considered a relatively uncommon finding; however, they related to poorer prognosis. Both primary GC and its metastatic progression rely on angiogenesis. Several lines of evidence patients strongly support the involvement mast cells (MCs) positive tryptase (MCPT) in tumor Recently, we analyzed infiltrating MCs neovascularization bone tissue patients, observed significant correlation between MCPT Such finding suggested peritumoral by surrounding cells, metastasis angiogenesis GC. Thus, an MCPT-stimulated angiogenic process could development tissue. From this perspective, aim review hypothetical tumor-infiltrating, angiogenesis-mediated cell growth microenvironment tumor-induced osteoclastic resorption. We also focus potential use targeting agents, such as inhibitors (gabexate mesylate, nafamostat mesylate) or c-KitR tyrosine kinase (imatinib, masitinib), possible new anti-angiogenic anti-resorptive strategies for treatment affected metastases.