Combination therapy to enhace nk cell mediated cytotoxicty
作者： Sherif S. Farag
DOI:
关键词: NKG2D 、 KIR2DL1 、 Cell 、 Receptor 、 Signal transduction 、 Biology 、 Lenalidomide 、 Cell surface receptor 、 Pharmacology 、 MAPK/ERK pathway
摘要: The function of natural killer (NK) cells is regulated by inhibitory and activating signals delivered cell surface receptors, 1-7F9 a fully human monoclonal antibody (mAb) directed against KIR2DL1 K1R2DL2/3 receptors that blocks its interaction with HLA-C ligands breaking NK tolerance to autologous tumor ceils. Lenalidomide has been shown increase cytotoxicity in vitro. combination lenalidomide enhanced mediated U266 beyond observed each agent alone. also increased the expression NKG2D, DNAM-I TRAIL including: MICA, ULB P2, CDl 12 DR 4 on cells. In vitro assays, susceptibility myeloma lines ceil. ceil signaling pathways was explored after treatment results show may upreguiate phospho-SHIPl (Tyrl020) no effect phospho-p44/42 (ERK 1/2) (Thr202/Tyr204) These provide pre¬ clinical rationale for investigation anti-KIR mAb MM.
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