Efficacy of pre-operative stereotactic radiosurgery followed by surgical resection and correlative radiobiological analysis for patients with 1–4 brain metastases: study protocol for a phase II trial

摘要: Stereotactic radiosurgery (SRS) has emerged as a common adjuvant modality used with surgery for resectable brain metastases (BMs). However, the optimal sequence of multi-modality therapy not been established. The goal study is to evaluate 6-month local control utilizing pre-operative SRS followed by surgical resection patients 1–4 metastases. This prospective, single arm, phase II trial will recruit up 4 and at least one lesion. All lesions be treated symptomatic resected within 1–4 days after SRS. Patients monitored control, in-brain progression free survival, distant failure, rate leptomeningeal spread, radiation necrosis overall survival. Additionally, we also perform correlative radiobiological molecular studies assess effect dosing on tumor tissue clinical outcomes. We expect that gross prior improve decrease failure. Our second prospective investigate efficacy in treatment multiple BMs. In addition, first early response BMs cellular genetic level doses potentially provide prognostic markers Clinicaltrials.gov identifier: NCT03398694 (registration date: January 12, 2018).